Skin irritation induced by topically applied timolol.

Topically applied ceramide accumulates in skin glyphs

Ceramides (CERs), structural components of the stratum corneum (SC), impart essential barrier properties to this thin outer layer of the epidermis. Variations in CER species within this layer have been linked to several skin diseases. A recent proliferation of CER-containing topical skin-care products warrants the elucidation of CER penetration profiles in both healthy and diseased skin. In the...

Skin irritation and corrosion.

Topically applied minoxidil in baldness.

Minoxidil, an orally administered, peripheral vasodilator used to treat hypertension, causes hypertrichosis in more than 80% of users. The drug reduces elevated blood pressure by decreasing peripheral vascular resistance. Chemically, minoxidil i s 2,4-diamino-6-piperidinopyrimidine-3-oxide; it is soluble in water to the extent of approximately 2 mg/ml, i s more readily soluble in propylene glyc...

Gangrene caused by topically applied home-prepared aconite liniment.

Conflicts of interest: No potential conflicts of interests are declared. of the crude drug Fu Zi, otherwise known as RadixAconiti Lateralis Praeparata (1). It contains aconitine-type alkaloids, and has been used to alleviate severe pain and to treat rheumatic diseases from ancient times (2). Many aconite poisoning cases have been reported, most resulting fromoraluse, producing systemic symptoms...

Khaki Drill and Skin Irritation

Sir,?The following facts may possibly be of interest to your readers and of use in cases similar to my own. For several years I suffered from an irritating skin disease which, without pathological examination of scrapings, was diagnosed variously as " tinea" or "lichen." Various doctors prescribed various ointments ?chrysarobin, benzoic, resorcin, salicylic, etc., etc., and iodine liniment, all...